Endocrine Abstracts

Hypophysitis is a heterogeneous inflammatory disease of pituitary gland. As it causes headache and visual defects, it mimics sellar tumors in clinical and radiological aspects. It may occur due to primary or secondary causes. Tuberculosis is one of the rare secondary causes of hypophysitis. A young male patient presented with fatigue and headache and diagnosed with tubercular hypophysitis as a result of performed tests is discussed hereby in the case report. A 30 year old male...

Aims: We aimed to determine the irisin level in patients with type 1 diabetes mellitus (T1DM) and to examine the relation of irisin level with inflammation and autoimmunity.Methods: This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Anti-glutamic acid decarboxylase (Anti-GAD), islet cell antibody (ICA), insulin autoantibody levels of the patients have been measured at the time they were included in the study and were recorded fro...

Objective: To investigate dynamic thiol/disulphide homeostasis in autoimmune subclinical hypothyroidism.Materials and methods: 48 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto’s thyroiditis and not yet on any treatment and 48 healthy subjects without any known disease were enrolled. Thiol/disulfide homeostasis (native thiol(-SH)–disulphide(-S-S-) exchanges) was measured in both groups with new method developed by Ere...

Objective: We aimed to investigate the effects of oxidative stress in the pathhogenesis and progression of thyroiditis in patients with Hashimoto’s thyroiditis whose aetiopathogenesis includes environmental and genetic factors.Methods: 80 patients (40 euthyroid and 40 subclinical hypothyroidism) older than 18 years with newly diagnosed Hashimoto’s thyroiditis and not yet on any treatment were enrolled. Patients were followed up for 9 months. Bl...

Background: In Hashimoto’s thyroiditis, chronic inflammation and autoimmunity increases oxidant radicals and cause oxidative stress. However, the effect of levothyroxine therapy on the oxidant and antioxidant systems is not known in overt hypothyroidism. Therefore, we sought to investigate the effect of levothyroxine sodium therapy on oxidative stress in patients with Hashimoto thyroiditis and overt hypothyroidism.Materials and methods: 36 patients ...

Background: The relationship between Hashimoto’s thyroiditis (HT) and oxidative stress (OS) has been investigated in several studies that have included a limited number of patients, the findings have not been conclusive, which indicates that additional research that investigates parameters of OS in larger patient populations is needed. As such, this dissertation study aimed to determine the levels of parameters of OS and their relationship with thyroid antibodies in HT pa...